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Project_03 Q30 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of quinpirole (0 0.0312 0.0625 0.125 0.25 and 0.5 mg/kg)

Description: This study (Q30) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q30 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of the first experiment in Q30 was "Effect of QNP dose (0 0.125 0.25 and 0.5 mg/kg) on the development of sensitization and compulsive checking (batch 1)". The title of the second experiment, which was a replication but with additional doses of quinpirole, was "Effect of QNP dose (0 0.0312 0.0625 0.125 0.25 and 0.5 mg/kg) on the development of sensitization and compulsive checking (batch 2)".
Authors: Szechtman, Henry; McMaster University; https://orcid.org/0000-0003-3986-4482 ORCID iD
Dvorkin-Gheva, Anna; McMaster University; https://orcid.org/0000-0001-7295-7440 ORCID iD
Keywords: animal model
obsessive compulsive disorder
OCD
compulsive checking behavior
exploration
locomotion
motor activity
behavioral sensitization
security motivation system
male rats Long-Evans
open field
large testing environment 160x160 cm
dopamine receptor agonist
chronic treatment with quinpirole (0.5 mg/kg)
chronic treatment with quinpirole (0.25 mg/kg)
chronic treatment with quinpirole (0.125 mg/kg)
chronic treatment with quinpirole (0.0625 mg/kg)
chronic treatment with quinpirole (0.0312 mg/kg)
repeated injections of saline vehicle
video recording
digitized track record
plot of routes of locomotion
repeated testing
repeated trials per rat 14
trials available 1570
number of rats 114
Field of Research: 
Biological sciences
>
Neurosciences, biological and chemical aspects
>
Behavioural neuroscience of reward and motivation

Basic medicine and life sciences
>
Neurosciences, medical and physiological and health aspects
>
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Psychology and cognitive sciences
>
Psychology, social and behavioural aspects
>
Psychopathology

Psychology and cognitive sciences
>
Cognitive sciences
>
Cognitive behaviour
Date: 2021-07-19
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
URI: https://doi.org/10.20383/102.0434
Related Identifiers: 



This dataset is supplemented by

This dataset is supplemented by


Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
City
Hamilton
Province /
Province / Territory
Ontario
Territory
 
Country
Canada
Geographic Point: 
Latitude
43.25978
Longitude
-79.91763
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H. , Dvorkin-Gheva, A. (2021) Project_03 Q30 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of quinpirole (0 0.0312 0.0625 0.125 0.25 and 0.5 mg/kg). Federated Research Data Repository. https://doi.org/10.20383/102.0434