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Project_04 Q33 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: acute treatment with escitalopram or imipramine
| Description: | This study (Q33) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q33 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of the experiment in Q33 was "Effect of acute escitalopram or imipramine on the expression of compulsive checking". Study Q33 was part also of a second project, Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking" where title of the experiment was "Effect of substitution of QNP with 8OHDPAT on the expression of sensitization and compulsive checking". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440 |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.2 mg/kg mg/kg) antidepressant drugs acute injection of escitalopram acute injection of imipramine serotonin receptor agonist cross-sensitization between quinpirole and 8OHDPAT repeated injections of saline vehicle
video recording
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digitized track record plot of routes of locomotion repeated testing repeated trials per rat 12 trials available 574 number of rats 48 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-07-08 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 |
| URI: | https://doi.org/10.20383/102.0432 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A. (2021). Project_04 Q33 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: acute treatment with escitalopram or imipramine. Federated Research Data Repository. https://doi.org/10.20383/102.0432
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