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Project_02 Q46 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
Description: | This study (Q46) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q46 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q46 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q46 is repeated as Study Q47 (hence "batch 1" in title of experiment for Q46). For Q46, each rat received 13 trials in the open field. |
Authors: | Szechtman, Henry; McMaster University; 0000-0003-3986-4482 Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440 |
Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.125 mg/kg) serotonin receptor agonist chronic treatment with 8OHDPAT (0.125 mg/kg) co-injections of quinpirole and 8OHDPAT dose-response study repeated injections of saline vehicle video recording
digitized track record
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plot of routes of locomotion repeated testing repeated trials per rat 13 trials available 728 number of rats 56 |
Field of Research: | Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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Publication Date: | 2021-07-06 |
Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
Funder: | Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant |
URI: | https://doi.org/10.20383/102.0419 |
Related Identifiers: |
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Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A. (2021). Project_02 Q46 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems. Federated Research Data Repository. https://doi.org/10.20383/102.0419