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Project_03 Q36 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of mCPP (0 0.3125 0.625 or 1.25 mg/kg)

Description: This study (Q36) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab.
The historical context for study Q36 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of experiment in Q36 was "Effect of mCPP dose (0 0.3125 0.625 or 1.25 mg/kg) on the development of sensitization and compulsive checking".
Authors: Szechtman, Henry; McMaster University; ORCID iD 0000-0003-3986-4482
Dvorkin-Gheva, Anna; McMaster University; ORCID iD 0000-0001-7295-7440
Tucci, Mark C.; McMaster University; Seneca Polytechnic
Keywords: Animal model
Obsessive compulsive disorder
OCD
Compulsive checking behavior
Exploration
Locomotion
Motor activity
Behavioral sensitization
Security motivation system
Male rats Long-Evans
Open field
Large testing environment 160x160 cm
Serotonin receptor agonist
Chronic treatments with mCPP (0.3125, 0.625 or 1.25 mg/kg)
Dopamine receptor agonist
Acute treatment with quinpirole (0.5 mg/kg)
Repeated injections of saline vehicle
Video recording
Digitized track record
Plot of routes of locomotion
Repeated testing
Repeated trials per rat 10
Trials available 554
Number of rats 56
Field of Research: 
Biological sciences
>
Neurosciences, biological and chemical aspects
>
Behavioural neuroscience of reward and motivation

Basic medicine and life sciences
>
Neurosciences, medical and physiological and health aspects
>
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Psychology and cognitive sciences
>
Psychology, social and behavioural aspects
>
Psychopathology

Psychology and cognitive sciences
>
Cognitive sciences
>
Cognitive behaviour
Publication Date: 2025-03-27
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Funder: Canadian Institutes of Health Research; Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424
URI: https://doi.org/10.20383/103.01237
Related Identifiers: 
This dataset is cited by
https://doi.org/10.1093/gigascience/giac092

This dataset cites
https://doi.org/10.1016/j.jneumeth.2003.10.013

This dataset is supplemented by
https://doi.org/10.1016/j.bbr.2006.01.024

This dataset is continued by
https://doi.org/10.20383/102.0426

This dataset is part/subset of
https://www.frdr-dfdr.ca/repo/collection/szechtmanlab

This dataset is the source of
https://doi.org/10.1007/s00213-013-2976-1

This dataset is the source of
http://hdl.handle.net/11375/16407
Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
City
Hamilton
Province /
Province / Territory
Ontario
Territory
 
Country
Canada
Geographic Point: 
Latitude
43.25978
Longitude
-79.91763
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Tucci, M. (2021). Project_03 Q36 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of mCPP (0 0.3125 0.625 or 1.25 mg/kg). Federated Research Data Repository. https://doi.org/10.20383/103.01237

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Version History
Version Date Summary
Version 2 2025-03-13 Added "smoothed" track files to the dataset. Specifically, added a transformed version of the RAWDATA csv track files stored in the folder "05_EthoVision_csvTrackFiles". The transformed version of the track files are stored in the folder "08_SEEprocessedTrackFiles". These files were pre-processed to remove noise from the digitized tracking data (by applying appropriate filters to smooth the x, y coordinates), as described in Dvorkin, A., Perreault, M. L., & Szechtman, H. (2006). Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder. Behavioural Brain Research, 169(2), 303-311. https://doi.org/10.1016/j.bbr.2006.01.024, according to methods described in Hen, I., Sakov, A., Kafkafi, N., Golani, I., & Benjamini, Y. (2004). The dynamics of spatial behavior: how can robust smoothing techniques help? Journal of Neuroscience Methods, 133(1-2), 161-172. http://dx.doi.org/10.1016/j.jneumeth.2003.10.013.

The RAWDATA csv track file and the smoothed version of it have the same name, except that the former has the suffix "_TrackFile.csv" while the latter has the suffix "_smoothed.csv"; e.g., Q36mCPP001_01_0_0009_0013186_TrackFile.csv and Q36mCPP001_01_0_0009_0013186_smoothed.csv, respectively.

The smoothed csv file has no header. Labels for the 5 columns in the smoothed csv file are: "Frame_#", "smoothed_x", "smoothed_y", "smoothed_velocity", "segment_type" (0=lingering, 1=movesegment).
Version 1 2021-07-05