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Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
| Description: | This study (Q47) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q47 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q47 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q47 was a repeat of Study Q46 (hence "batch 2" in title of experiment for Q47). For Q47, like for Q46 (dataset doi: 10.20383/102.0419), each rat received 13 trials in the open field. However, in IDStudy Q47, rats received a 14th trial in the open field, but for this test the open field was emptied of the 4 objects normally in it. This particular trial is grouped under Project_09 ("Probing the environmental modulation of sensitization and compulsive checking"), giving IDStudy Q47 a second title, "Probing the environmental modulation of sensitization and compulsive checking: influence of no objects in the open field on expression". The historical context for IDStudy Q47 includes the introduction of "enriched" housing, that is, a piece of black plastic tube was placed in the rat's home cage (prior to this study, there were no objects in the home cage). A comparison of study Q47 with Q46 showed that "enriched" housing did not influence the development of sensitization or compulsive checking |
| Authors: | Szechtman, Henry; McMaster University; https://orcid.org/0000-0003-3986-4482  Dvorkin-Gheva, Anna; McMaster University; https://orcid.org/0000-0001-7295-7440 |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.125 mg/kg) serotonin receptor agonist chronic treatment with 8OHDPAT (0.125 mg/kg) co-injections of quinpirole and 8OHDPAT dose-response study repeated injections of saline vehicle video recording
digitized track record
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plot of routes of locomotion repeated testing repeated trials per rat 14 trials available 773 number of rats 56 |
| Field of Research: | Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of learning and memory
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Date: | 2021-07-14 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| URI: | https://doi.org/10.20383/102.0418 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H. , Dvorkin-Gheva, A. (2021) Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems. Federated Research Data Repository. https://doi.org/10.20383/102.0418
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