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Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems

Description: This study (Q47) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q47 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q47 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q47 was a repeat of Study Q46 (hence "batch 2" in title of experiment for Q47). For Q47, like for Q46 (dataset doi: 10.20383/102.0419), each rat received 13 trials in the open field. However, in IDStudy Q47, rats received a 14th trial in the open field, but for this test the open field was emptied of the 4 objects normally in it. This particular trial is grouped under Project_09 ("Probing the environmental modulation of sensitization and compulsive checking"), giving IDStudy Q47 a second title, "Probing the environmental modulation of sensitization and compulsive checking: influence of no objects in the open field on expression". The historical context for IDStudy Q47 includes the introduction of "enriched" housing, that is, a piece of black plastic tube was placed in the rat's home cage (prior to this study, there were no objects in the home cage). A comparison of study Q47 with Q46 showed that "enriched" housing did not influence the development of sensitization or compulsive checking
Authors: Szechtman, Henry; McMaster University; ORCID iD 0000-0003-3986-4482
Dvorkin-Gheva, Anna; McMaster University; ORCID iD 0000-0001-7295-7440
Keywords: animal model
obsessive compulsive disorder
OCD
compulsive checking behavior
exploration
locomotion
motor activity
behavioral sensitization
security motivation system
male rats Long-Evans
open field
large testing environment 160x160 cm
dopamine receptor agonist
chronic treatment with quinpirole (0.125 mg/kg)
serotonin receptor agonist
chronic treatment with 8OHDPAT (0.125 mg/kg)
co-injections of quinpirole and 8OHDPAT
dose-response study
repeated injections of saline vehicle
video recording
digitized track record
plot of routes of locomotion
repeated testing
repeated trials per rat 14
trials available 773
number of rats 56
Field of Research: 
Basic medicine and life sciences
>
Neurosciences, medical and physiological and health aspects
>
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Biological sciences
>
Neurosciences, biological and chemical aspects
>
Behavioural neuroscience of learning and memory

Psychology and cognitive sciences
>
Psychology, social and behavioural aspects
>
Psychopathology

Psychology and cognitive sciences
>
Cognitive sciences
>
Cognitive behaviour
Publication Date: 2021-07-14
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Funder: Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant
URI: https://doi.org/10.20383/102.0418
Related Identifiers: 
This dataset continues

Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
City
Hamilton
Province /
Province / Territory
Ontario
Territory
 
Country
Canada
Geographic Point: 
Latitude
43.25978
Longitude
-79.91763
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A. (2021). Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems. Federated Research Data Repository. https://doi.org/10.20383/102.0418