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Project_11 Q48 StudyTitle Probing for biological markers of the pathogenesis of compulsive checking: mRNA expression and changes in gut microbiota
| Description: | This study (Q48) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing RAWDATA objects (video, track, path plot and EthoVision files) of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q48 was Project_11 entitled: "Probing for biological markers of the pathogenesis of compulsive checking". The particular question investigated in Q48 was whether the developments of compulsive checking and locomotor sensitization were accompanied by changes in gene expression and microbiome composition. Findings of gut microbiota changes during induction of compulsive checking and sensitization to quinpirole had been published (https://doi.org/10.1097/FBP.0000000000000363). Results of mRNA expression were inconclusive and not published; raw data are included in sub-folder 11_SPSS_savMasterFiles. Aside the RAWDAA objects (video, track, path plot, and EthoVision files) provided by every study in the Szechtman Lab Collection, study Q48 deposit contains derived data for measures of compulsive checking and locomotion as well as files that document specifics of the study, as described in the README.txt file. |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440 |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.25 mg/kg) repeated injections of saline vehicle video recording digitized track record plot of routes of locomotion repeated testing number of repeated trials per rat 9
total trials from study 281
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number of rats in study 31 energy metabolism microbiome |
| Field of Research: | Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-06-21 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant |
| URI: | https://doi.org/10.20383/102.0417 |
| Related Identifiers: |
This dataset is cited by
This dataset is supplemented by
This dataset is part/subset of
This dataset is the source of
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| Geographic Coverage: | Place Name Health Sciences Centre U58, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada Place Name Health Sciences Centre U59, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada Place Name Health Sciences Centre 4N7, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A. (2021). Project_11 Q48 StudyTitle Probing for biological markers of the pathogenesis of compulsive checking: mRNA expression and changes in gut microbiota. Federated Research Data Repository. https://doi.org/10.20383/102.0417
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