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Project_05 Q44 StudyTitle Probing the mode of action of mCPP on compulsive checking: 5-HT2A/C receptors
| Description: | This study (Q44) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q44 was Project_05 entitled: "Probing the mode of action of mCPP on compulsive checking". Title of experiment in Q44 was "Effect of ritanserin (5-HT2A/C receptors blocker) on the attenuation by mCPP of the expression of quinpirole-induced compulsive checking". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Tucci, Mark C.; McMaster University; Seneca College |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.125 mg/kg) serotonin receptor agonist acute treatment with mCPP (1.25 mg/kg) serotonin receptor blocker acute treatment with ritanserin (1 mg/kg or 5 mg/kg) co-injections of quinpirole and mCPP and ritanserin repeated injections of saline vehicle
video recording
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digitized track record plot of routes of locomotion repeated testing repeated trials per rat 13 trials available 638 number of rats 56 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
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| Publication Date: | 2021-06-28 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 |
| URI: | https://doi.org/10.20383/102.0421 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada Place Name McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada Place Name McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Tucci, M. (2021). Project_05 Q44 StudyTitle Probing the mode of action of mCPP on compulsive checking: 5-HT2A/C receptors. Federated Research Data Repository. https://doi.org/10.20383/102.0421
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