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Project_06 Q17 StudyTitle Probing the mode of action of quinpirole on behavior: role of the monoamine oxidase inhibitor (MAOI) sensitive quinpirole binding site (MQB)
| Description: | This study (Q17) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q17 was Project_06 entitled: "Probing the mode of action of quinpirole on behavior". Title of experiment in Q17 was "Differential effects of clorgyline (a MAO inhibitor) on sensitization to QNP in rats tested in small and large environments". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Culver, Kirsten E.; McMaster University Waxman, Donna; McMaster University |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm locomotor activity chambers 40x40x35 cm video recording of 5 trials in locomotor activity chambers dopamine receptor agonist chronic treatment with quinpirole (0.5 mg/kg) MAO inhibitor clorgyline chronic treatment with clorgyline (1 mg/kg/day via osmotic minipump) quinpirole and clorgyline co-treatment video recording
digitized track record
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plot of routes of locomotion repeated testing repeated open field trials per rat 1 or 10 trials available 137 number of rats 24 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-07-30 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behavior; MT-12852 Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 |
| URI: | https://doi.org/10.20383/102.0445 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Culver, K., Waxman, D. (2021). Project_06 Q17 StudyTitle Probing the mode of action of quinpirole on behavior: role of the monoamine oxidase inhibitor (MAOI) sensitive quinpirole binding site (MQB). Federated Research Data Repository. https://doi.org/10.20383/102.0445
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