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Project_01 Q26 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development, and, on expression
| Description: | This study (Q26) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q26 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". This project had two separate studies, designated as Q26NAc1 and Q26NAc2. The title of study Q26NAc1 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development" and the title of study Q26NAc2 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on expression". Study Q26NAc1 had two experiments, the first one with the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 1)" and the second one, which was a repeat of the first experiment, had the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 2)". The title of experiment in Q26NAc2 was "Effect of an NMDA lesion of the NAc on the expression of sensitization and compulsive checking". For the development study (Q26NAc1), rats received a lesion targeted at the NAc and the effect of this lesion on the induction of compulsive checking in our standard paradigm was measured. For the expression study (Q26NAc2), rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the NAc and the effect of this lesion on the expression of compulsive checking was measured. This dataset has the same Design and Procedure as dataset deposits for StudyID Q25 doi:10.20383/102.0439 and StudyID Q28 doi:10.20383/102.0436 |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Silva, Charmaine A.; McMaster University; University Health Network Ballester Gonzalez, Javier; McMaster University; University of Utah; 0000-0002-5604-0939 |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.5 mg/kg) nucleus accumbens core (NAc) NMDA lesion lesion effect on development of response to repeated treatment lesion effect on expression of established behavior repeated injections of saline vehicle video recording digitized track record
plot of routes of locomotion
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repeated testing repeated trials per rat 14 trials available 2303 number of rats 176 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-08-06 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant |
| URI: | https://doi.org/10.20383/102.0438 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Silva, C., Ballester Gonzalez, J. (2021). Project_01 Q26 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development, and, on expression. Federated Research Data Repository. https://doi.org/10.20383/102.0438
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