Project_01 Q26 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development, and, on expression

Szechtman, Henry

https://ror.org/02fa3aq29

McMaster University

https://orcid.org/0000-0003-3986-4482

Dvorkin-Gheva, Anna

https://ror.org/02fa3aq29

McMaster University

https://orcid.org/0000-0001-7295-7440

Silva, Charmaine A.

https://ror.org/02fa3aq29;https://ror.org/042xt5161

McMaster University; University Health Network

Ballester Gonzalez, Javier

https://ror.org/02fa3aq29;https://ror.org/03r0ha626

McMaster University; University of Utah

https://orcid.org/0000-0002-5604-0939

2021-08-06T14:15:37Z

2021-08-06T14:15:37Z

2021-08-06

https://www.frdr-dfdr.ca/repo/dataset/bd65def5-ba71-48c7-a774-5f2321c4a951

https://doi.org/10.20383/102.0438

This study (Q26) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q26 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". This project had two separate studies, designated as Q26NAc1 and Q26NAc2. The title of study Q26NAc1 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development" and the title of study Q26NAc2 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on expression". Study Q26NAc1 had two experiments, the first one with the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 1)" and the second one, which was a repeat of the first experiment, had the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 2)". The title of experiment in Q26NAc2 was "Effect of an NMDA lesion of the NAc on the expression of sensitization and compulsive checking". For the development study (Q26NAc1), rats received a lesion targeted at the NAc and the effect of this lesion on the induction of compulsive checking in our standard paradigm was measured. For the expression study (Q26NAc2), rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the NAc and the effect of this lesion on the expression of compulsive checking was measured. This dataset has the same Design and Procedure as dataset deposits for StudyID Q25 doi:10.20383/102.0439 and StudyID Q28 doi:10.20383/102.0436

Federated Research Data Repository / dépôt fédéré de données de recherche

Creative Commons Attribution 4.0 International (CC BY 4.0)

https://creativecommons.org/licenses/by/4.0/

animal model

obsessive compulsive disorder

OCD

compulsive checking behavior

exploration

locomotion

motor activity

behavioral sensitization

security motivation system

male rats Long-Evans

open field

large testing environment 160x160 cm

dopamine receptor agonist

chronic treatment with quinpirole (0.5 mg/kg)

nucleus accumbens core (NAc) NMDA lesion

lesion effect on development of response to repeated treatment

lesion effect on expression of established behavior

repeated injections of saline vehicle

video recording

digitized track record

plot of routes of locomotion

repeated testing

repeated trials per rat 14

trials available 2303

number of rats 176

Project_01 Q26 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development, and, on expression

f163c1b3-9c88-42f6-a7bb-5839ed6c4063

/11/published/publication_433/

2021

2006-05-08/2006-06-23

2006-09-18/2006-11-24

2008-02-18/2008-04-04

Dataset

https://doi.org/10.1093/gigascience/giac092

https://doi.org/10.1037/0735-7044.112.6.1475

https://doi.org/10.1016/j.jneumeth.2003.10.013

https://doi.org/10.1111/j.1460-9568.2010.07398.x

https://doi.org/10.1097/FBP.0000000000000112

https://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=018027bf-217d-4528-96d2-ca65cb5e58e3&cKey=5013e7da-20d9-4640-8685-65c90ae92dff&mKey=%7bAFEA068D-D012-4520-8E42-10E4D1AF7944%7d

https://www.ibnsconnect.org/assets/docs/pastprograms/ibnsprogram2009final.pdf

https://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=2fd47965-8611-4f34-96fc-c683f4b84874&cKey=39a2326e-38ac-40fc-b6d1-e2e7cb1aa0c1&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d

http://discovery.mcmaster.ca/iii/encore/record/C__Rb1585773

https://doi.org/10.1016/j.bbr.2006.01.024

https://doi.org/10.20383/102.0436

https://doi.org/10.20383/102.0439

https://www.frdr-dfdr.ca/repo/collection/szechtmanlab

43.25978 -79.91763

Health Sciences Centre, McMaster University;Hamilton;Ontario;Canada

Canadian Institutes of Health Research (CIHR)

MOP-64424

Dopamine, movements, motion and behaviour: Animal model of OCD

Natural Sciences and Engineering Research Council of Canada (NSERC)

RGPIN A0544

Ontario Mental Health Foundation (OMHF)

Type A Grant

Psychobiology of security motivation in an animal model of OCD

RDF1061106

Biological sciences

Neurosciences, biological and chemical aspects

Behavioural neuroscience of reward and motivation

Sciences biologiques

Neurosciences, aspects biologiques et chimiques

Neurosciences comportementales de la récompense et de la motivation

RDF3010499

Basic medicine and life sciences

Neurosciences, medical and physiological and health aspects

Neurosciences, medical and health and physiological aspects, not elsewhere classified

Médecine fondamentale et sciences de la vie

Neurosciences, aspects médicaux et physiologiques et de la santé

Neurosciences, aspects médicaux, physiologiques, et de la santé, non classé ailleurs

RDF5010113

Psychology and cognitive sciences

Psychology, social and behavioural aspects

Psychopathology

Psychologie et sciences cognitives

Psychologie, aspects sociaux et comportementaux

Psychopathologie

RDF5010208

Psychology and cognitive sciences

Cognitive sciences

Cognitive behaviour

Psychologie et sciences cognitives

Sciences cognitives

Comportement cognitif