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Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes

Description: A DNA library with glycyl–histidine-functionalized tertiary amine moiety modification at the cleavage junction was used for in vitro selection of Zn2+-dependent DNAzyme. Four DNAzymes were isolated and each of these DNAzymes displays different cooperative binding of metal ions. An interesting relationship between the number of metal ions involved in DNAzyme catalysis and selectivity was established, and this study showed that it could be a useful way to develop highly specific metal sensors.
Authors: Huang, Po-Jung Jimmy; Water Institute; University of Waterloo; https://orcid.org/0000-0003-3436-996 ORCID iD
de Rochambeau, Donatien; McGill University
Sleiman, Hanadi F.; McGill University; https://orcid.org/0000-0002-5100-0532 ORCID iD
Liu, Juewen; Water Institute; University of Waterloo; https://orcid.org/0000-0001-5918-9336 ORCID iD
Keywords: DNAzyme
Biosensor
Zinc
Date: 2021-03-12
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
URI: https://doi.org/10.20383/102.0346
Related Identifiers: 
This dataset is a supplement to
Appears in Collections:Water Institute

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Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Huang, P. , de Rochambeau, D. , Sleiman, H. , Liu, J. (2021) Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes. Federated Research Data Repository. https://doi.org/10.20383/102.0346