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Project_04 Q38 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: effect of mCPP dose (0 0.625 and 1.25 mg/kg) on development produced by a medium dose of QNP (0.25 mg/kg)

Description: This study (Q38) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q38 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of experiment in Q38 was "Effect of mCPP dose (0.625 and 1.25 mg/kg) co-injected with a fixed dose of QNP (0.25 mg/kg) on the development of sensitization and compulsive checking".
Authors: Szechtman, Henry; McMaster University; ORCID iD 0000-0003-3986-4482
Dvorkin-Gheva, Anna; McMaster University; ORCID iD 0000-0001-7295-7440
Tucci, Mark C.; McMaster University; Seneca College
Keywords: animal model
obsessive compulsive disorder
OCD
compulsive checking behavior
exploration
locomotion
motor activity
behavioral sensitization
security motivation system
male rats Long-Evans
open field
large testing environment 160x160 cm
serotonin receptor agonist
chronic treatments with mCPP (0.625 or 1.25 mg/kg)
dopamine receptor agonist
chronic treatment with quinpirole (0.25 mg/kg)
repeated injections of saline vehicle
video recording
digitized track record
plot of routes of locomotion
repeated testing
repeated trials per rat 12
trials available 635
number of rats 56
Field of Research: 
Biological sciences
>
Neurosciences, biological and chemical aspects
>
Behavioural neuroscience of reward and motivation

Basic medicine and life sciences
>
Neurosciences, medical and physiological and health aspects
>
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Psychology and cognitive sciences
>
Psychology, social and behavioural aspects
>
Psychopathology

Psychology and cognitive sciences
>
Cognitive sciences
>
Cognitive behaviour
Publication Date: 2021-07-06
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Funder: Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424
Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544
Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant
URI: https://doi.org/10.20383/102.0427
Related Identifiers: 

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This dataset is the source of
Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
City
Hamilton
Province /
Province / Territory
Ontario
Territory
 
Country
Canada
Geographic Point: 
Latitude
43.25978
Longitude
-79.91763
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Tucci, M. (2021). Project_04 Q38 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: effect of mCPP dose (0 0.625 and 1.25 mg/kg) on development produced by a medium dose of QNP (0.25 mg/kg). Federated Research Data Repository. https://doi.org/10.20383/102.0427