Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression

Szechtman, Henry

https://ror.org/02fa3aq29

McMaster University

https://orcid.org/0000-0003-3986-4482

Dvorkin-Gheva, Anna

https://ror.org/02fa3aq29

McMaster University

https://orcid.org/0000-0001-7295-7440

Ray, Laura B.

https://ror.org/02fa3aq29;-

McMaster University; Sleep Well

2021-08-06T16:36:13Z

2021-08-06T16:36:13Z

2021-08-06

https://www.frdr-dfdr.ca/repo/dataset/d63c82f9-0c9d-4c3f-b44a-1144baa72289

https://doi.org/10.20383/102.0442

This study (Q22) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab.
The historical context for study Q22 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". Title of the experiment in Q22 was "Effect of an NMDA lesion of the infralimbic ctx on expression of compulsive checking". For this expression study, rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the infralimbic cortex (IL) and the effect of this lesion on the expression of compulsive checking was measured. This experiment was run in 3 batches to refine success in lesioning IL. Study Q22 was also part of a second project, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where title of the experiment was "Effect of testing under infra-red illumination on the expression of sensitization and compulsive checking". This experiment was an add-on for batch 2 rats where at the end of prescribed testing, rats received two more trials (injections 14 and 15) to compare performance under usual illumination with performance under darkness with no visible light in the testing room.

Federated Research Data Repository / dépôt fédéré de données de recherche

Creative Commons Attribution 4.0 International (CC BY 4.0)

https://creativecommons.org/licenses/by/4.0/

animal model

obsessive compulsive disorder

OCD

compulsive checking behavior

exploration

locomotion

motor activity

behavioral sensitization

security motivation system

male rats Long-Evans

open field

large testing environment 160x160 cm

dopamine receptor agonist

chronic treatment with quinpirole (0.5 mg/kg)

infralimbic cortex (ILc) NMDA lesion

lesion effect on expression of established behavior

repeated injections of saline vehicle

video recording

digitized track record

plot of routes of locomotion

repeated testing

repeated trials per rat 14 or 15

trials available 1717

number of rats 120

Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression

c1ed357d-e294-4cba-9617-4b56890c42ae

/11/published/publication_437/

AIP #1: 2024-01-03
AIP #2: 2024-01-13
AIP #3
AIP #4: 2024-01-04
AIP #5: 2024-01-04

2021

2004-01-27/2004-03-23

2004-05-18/2004-07-14

2005-05-02/2005-07-01

2004-07-20/2004-07-30

Dataset

https://doi.org/10.1093/gigascience/giac092

https://doi.org/10.1037/0735-7044.112.6.1475

https://doi.org/10.1016/j.jneumeth.2003.10.013

https://www.sfn.org/meetings/past-and-future-annual-meetings/abstract-archive/abstract-archive-details?absID=13513&absyear=2004

http://discovery.mcmaster.ca/iii/encore/record/C__Rb1576567

https://doi.org/10.1016/j.bbr.2006.01.024

https://doi.org/10.1111/j.1460-9568.2010.07398.x

https://www.frdr-dfdr.ca/repo/collection/szechtmanlab

43.25978 -79.91763

Health Sciences Centre, McMaster University;Hamilton;Ontario;Canada

Canadian Institutes of Health Research (CIHR)

MOP-64424

Dopamine, movements, motion and behaviour: Animal model of OCD

Natural Sciences and Engineering Research Council of Canada (NSERC)

RGPIN A0544

RDF1061106

Biological sciences

Neurosciences, biological and chemical aspects

Behavioural neuroscience of reward and motivation

Sciences biologiques

Neurosciences, aspects biologiques et chimiques

Neurosciences comportementales de la récompense et de la motivation

RDF3010499

Basic medicine and life sciences

Neurosciences, medical and physiological and health aspects

Neurosciences, medical and health and physiological aspects, not elsewhere classified

Médecine fondamentale et sciences de la vie

Neurosciences, aspects médicaux et physiologiques et de la santé

Neurosciences, aspects médicaux, physiologiques, et de la santé, non classé ailleurs

RDF5010113

Psychology and cognitive sciences

Psychology, social and behavioural aspects

Psychopathology

Psychologie et sciences cognitives

Psychologie, aspects sociaux et comportementaux

Psychopathologie

RDF5010208

Psychology and cognitive sciences

Cognitive sciences

Cognitive behaviour

Psychologie et sciences cognitives

Sciences cognitives

Comportement cognitif