Skip Navigation

How to Download

FRDR offers multiple ways to download datasets. Learn more in our documentation.

Project_03 Q35 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of 8OHDPAT (0 0.03 0.125 0.25 and 1 mg/kg)

Description: This study (Q35) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab.
The historical context for study Q35 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of experiment in Q35 was "Effect of 8OHDPAT dose (0 0.03 0.125 0.25 and 1 mg/kg) on the development of sensitization and compulsive checking".
Study Q35 was part also of a second project, Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking" where title of the experiment was "Effect of acute escitalopram on the expression of sensitization and compulsive checking".
Authors: Szechtman, Henry; McMaster University; ORCID iD 0000-0003-3986-4482
Dvorkin-Gheva, Anna; McMaster University; ORCID iD 0000-0001-7295-7440
Alkhatib, Ahmad Hamdi; McMaster University; ORCID iD 0000-0003-3246-817X
Keywords: animal model
obsessive compulsive disorder
OCD
compulsive checking behavior
exploration
locomotion
motor activity
behavioral sensitization
security motivation system
male rats Long-Evans
open field
large testing environment 160x160 cm
serotonin receptor agonist
chronic treatment with 8OHDPAT (0.03 0.125 0.25, 1 mg/kg)
acute injection of escitalopram
repeated injections of saline vehicle
video recording
digitized track record
plot of routes of locomotion
repeated testing
repeated trials per rat 15
trials available 840
number of rats 56
Field of Research: 
Biological sciences
>
Neurosciences, biological and chemical aspects
>
Behavioural neuroscience of reward and motivation

Basic medicine and life sciences
>
Neurosciences, medical and physiological and health aspects
>
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Psychology and cognitive sciences
>
Psychology, social and behavioural aspects
>
Psychopathology

Psychology and cognitive sciences
>
Cognitive sciences
>
Cognitive behaviour
Publication Date: 2021-07-19
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Funder: Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424
Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant
URI: https://doi.org/10.20383/102.0430
Related Identifiers: 




This dataset is supplemented by

This dataset is supplemented by


Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
City
Hamilton
Province /
Province / Territory
Ontario
Territory
 
Country
Canada
Geographic Point: 
Latitude
43.25978
Longitude
-79.91763
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

Files in Dataset 
No files uploaded
Download entire dataset using Globus Transfer. This method requires a Globus account and installing software. Watch Video: Get Started with FRDR: Download a Dataset
Download with Globus
Files for this dataset are currently being backed up so it cannot be approved at this time. Please try later.

Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Alkhatib, A. (2021). Project_03 Q35 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of 8OHDPAT (0 0.03 0.125 0.25 and 1 mg/kg). Federated Research Data Repository. https://doi.org/10.20383/102.0430