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Project_12 Q41 StudyTitle Resynthesis of compulsive checking: NAc lesion plus mCPP (0.625 mg/kg) on injections 1-6 and 8OHDPAT (0.0625 mg/kg) on injections 7-10
| Description: | This study (Q41) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q41 was Project_12 entitled: "Resynthesis of compulsive checking". Title of experiment in Q41 was "Effects of NAc lesion plus mCPP (0.625 mg/kg on injections 1-6) or 8OHDPAT (.0625 mg/kg on injections 7-10) in producing compulsive checking". Study Q41 is continued as Study Q42 (dataset deposit doi: 110.20383/102.0423). |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Tucci, Mark C.; McMaster University; Seneca College |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm serotonin receptor agonist chronic treatment with mCPP (0.625 mg/kg) chronic treatment with 8OHDPAT (0.0625 mg/kg) nucleus accumbens core NMDA lesion repeated injections of saline vehicle video recording digitized track record plot of routes of locomotion
repeated testing
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repeated trials per rat 10 trials available 505 number of rats 52 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-07-02 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 Ontario Mental Health Foundation (OMHF); Psychobiology of security motivation in an animal model of OCD; Type A Grant |
| URI: | https://doi.org/10.20383/102.0424 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Tucci, M. (2021). Project_12 Q41 StudyTitle Resynthesis of compulsive checking: NAc lesion plus mCPP (0.625 mg/kg) on injections 1-6 and 8OHDPAT (0.0625 mg/kg) on injections 7-10. Federated Research Data Repository. https://doi.org/10.20383/102.0424
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