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Project_02 Q34 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
| Description: | This study (Q34) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q34 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of the fist experiment in Q34 was "Comparison of the QNP (0.2 mg/kg) and the 8OHDPAT (1 mg/kg) effects on the development of sensitization and compulsive checking". Title of the second experiment in Q34 was "Effect of QNP+8OHDPAT co-treatment on the expression of sensitization and compulsive checking" Study Q34 was part also of a second project, Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking" where title of the experiment was "Effect of acute escitalopram on the expression of sensitization and compulsive checking". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Alkhatib, Ahmad Hamdi; McMaster University; 0000-0003-3246-817X |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm serotonin receptor agonist chronic treatment with 8OHDPAT (1 mg/kg) chronic treatment with quinpirole (0.2 mg/kg mg/kg) acute co-injection of 8OHDPAT (1 mg/kg) and quinpirole (0.2 mg/kg) acute injection of escitalopram repeated injections of saline vehicle video recording digitized track record
plot of routes of locomotion
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repeated testing repeated trials per rat 16-17 trials available 582 number of rats 36 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-07-19 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 |
| URI: | https://doi.org/10.20383/102.0431 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Alkhatib, A. (2021). Project_02 Q34 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems. Federated Research Data Repository. https://doi.org/10.20383/102.0431
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