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Project_03 Q36 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of mCPP (0 0.3125 0.625 or 1.25 mg/kg)
| Description: | This study (Q36) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q36 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of experiment in Q36 was "Effect of mCPP dose (0 0.3125 0.625 or 1.25 mg/kg) on the development of sensitization and compulsive checking". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Tucci, Mark C.; McMaster University; Seneca College |
| Keywords: | Animal model Obsessive compulsive disorder OCD Compulsive checking behavior Exploration Locomotion Motor activity Behavioral sensitization Security motivation system Male rats Long-Evans Open field Large testing environment 160x160 cm Serotonin receptor agonist Chronic treatments with mCPP (0.3125, 0.625 or 1.25 mg/kg) Dopamine receptor agonist Acute treatment with quinpirole (0.5 mg/kg) Repeated injections of saline vehicle Video recording Digitized track record Plot of routes of locomotion
Repeated testing
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Repeated trials per rat 10 Trials available 554 Number of rats 56 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-07-05 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 |
| URI: | https://doi.org/10.20383/102.0429 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Tucci, M. (2021). Project_03 Q36 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of mCPP (0 0.3125 0.625 or 1.25 mg/kg). Federated Research Data Repository. https://doi.org/10.20383/102.0429
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