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Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes
| Description: | A DNA library with glycyl–histidine-functionalized tertiary amine moiety modification at the cleavage junction was used for in vitro selection of Zn2+-dependent DNAzyme. Four DNAzymes were isolated and each of these DNAzymes displays different cooperative binding of metal ions. An interesting relationship between the number of metal ions involved in DNAzyme catalysis and selectivity was established, and this study showed that it could be a useful way to develop highly specific metal sensors. |
| Authors: | Huang, Po-Jung Jimmy; Water Institute; University of Waterloo;  0000-0003-3436-996de Rochambeau, Donatien; McGill University Sleiman, Hanadi F.; McGill University; 0000-0002-5100-0532Liu, Juewen; Water Institute; University of Waterloo; 0000-0001-5918-9336 |
| Keywords: | DNAzyme Biosensor Zinc |
| Field of Research: | Biological sciences > Biochemistry > Analytical biochemistry
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| Publication Date: | 2021-03-12 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Natural Sciences and Engineering Research Council of Canada (NSERC) Canada First Research Excellence Fund (CFREF); Global Water Futures Program (GWF) Global Water Futures (GWF) Canada Research Chairs (CRC); Canada Research Chair in DNA Nanoscience |
| URI: | https://doi.org/10.20383/102.0346 |
| Related Identifiers: |
This dataset is a supplement to
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| Appears in Collections: | Water Institute |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Huang, P., de Rochambeau, D., Sleiman, H., Liu, J. (2021). Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes. Federated Research Data Repository. https://doi.org/10.20383/102.0346
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