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Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues
| Description: | With the growing consumption of caffeine-containing beverages, detection of caffeine has become an important biomedical, bioanalytical, and environmental topic. Four high-quality aptamers for caffeine were isolated and were carefully characterized. A structure-switching fluorescent sensor was designed showing a detection limit of 1.2 μM caffeine, which reflected the labeled caffeine concentration within 6.1% difference for eight commercial beverages. In 20% human serum, a detection limit of 4.0 μM caffeine was achieved. In addition, these four fluorescent aptamer sensors can form a sensing array, caffeine and the three analogues were well separated from nine other closely related molecules. |
| Notes: | Dataset is from the publication "Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues" https://doi.org/10.1021/acs.analchem.1c04349 Item exited embargo and became publicly available on 2022-06-10 L’élément est sorti de sa période d’embargo et est devenu public le 2022-06-10 Le jeu de données est sorti de sa période d’embargo et est devenu public le 2022-06-01 |
| Authors: | Huang, Po-Jung Jimmy; University of Waterloo; https://orcid.org/0000-0003-3436-9968  Liu, Juewen; University of Waterloo; https://orcid.org/0000-0001-5918-9336 |
| Keywords: | DNA SELEX fluorescence Aptamer Caffeine Biosensor |
| Field of Research: | Biological sciences > Biochemistry > Analytical biochemistry
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| Publication Date: | 2022-06-10 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| URI: | https://doi.org/10.20383/103.0587 |
| Related Identifiers: |
This dataset is cited by
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| Geographic Coverage: | Place Name University of Waterloo City Waterloo Province / Province / Territory Ontario Territory Country Canada |
| Appears in Collections: | Water Institute |
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Access to this dataset is subject to the following terms:
Creative Commons Public Domain Dedication (CC0 1.0) https://creativecommons.org/publicdomain/zero/1.0/
Citation
Huang, P., Liu, J. (2022). Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues. Federated Research Data Repository. https://doi.org/10.20383/103.0587
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