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A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla

Description: Multimodal microstructural MRI has shown increased sensitivity and specificity to changes in various brain disease and injury models in the preclinical setting. Here, we present an in vivo longitudinal dataset, acquired as control data and to investigate microstructural changes in the healthy mouse brain. The dataset consists of structural T2-weighted imaging, magnetization transfer ratio and saturation imaging, and advanced quantitative diffusion MRI (dMRI) methods. The dMRI methods include oscillating gradient spin echo (OGSE) dMRI and microscopic anisotropy (μA) dMRI, which provide additional insight by increasing sensitivity to smaller spatial scales and disentangling fiber orientation dispersion from true microstructural changes, respectively. The technical skills required to analyze microstructural MRI data are complex and include MRI sequence development, acquisition, and computational neuroimaging expertise. Here, we share unprocessed and preprocessed data, and scalar maps of quantitative MRI metrics. We envision utility of this dataset in the microstructural MRI field to develop and test biophysical models, methods that model temporal brain dynamics, and different registration and preprocessing pipelines.
Notes: This dataset is made available under a CC-BY license <>, however, the file code_scidata_paper/niiCombDiffAve/MPdenoising.m has an additional non-commercial clause and may only be used or copied for non-commercial research. Please cite Jelle Veraart (2016) and see the file header for its full terms of use. In addition, the Turone Mouse Brain Template and Atlas in Registration/atlas/TMBTA_Brain_Template and Registration/atlas/TMBTA_Brain_Labels may only be used for non-commercial purposes. Please cite David André Barrière (2019) and visit in the NeuroImaging Tools and Resources Collaboratory for full terms of use.
Authors: Rahman, Naila; Western University
Xu, Kathy; Western University
Budde, Matthew D.; Medical College of Wisconsin
Brown, Arthur; Western University
Baron, Corey A.; Western University
Keywords: Diffusion MRI
Magnetization Transfer MRI
Longitudinal in vivo Imaging
Multimodal MRI
Rodent brain
Field of Research: 
Basic medicine and life sciences
Neurosciences, medical and physiological and health aspects
Central nervous system
Publication Date: 2022-07-07
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Related Identifiers: 
Geographic Coverage: 
Place Name
Robarts Research Institute, University of Western Ontario
Province /
Province / Territory

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0)
Rahman, N., Xu, K., Budde, M., Brown, A., Baron, C. (2022). A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla. Federated Research Data Repository.