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Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression
| Description: | This study (Q22) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q22 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". Title of the experiment in Q22 was "Effect of an NMDA lesion of the infralimbic ctx on expression of compulsive checking". For this expression study, rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the infralimbic cortex (IL) and the effect of this lesion on the expression of compulsive checking was measured. This experiment was run in 3 batches to refine success in lesioning IL. Study Q22 was also part of a second project, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where title of the experiment was "Effect of testing under infra-red illumination on the expression of sensitization and compulsive checking". This experiment was an add-on for batch 2 rats where at the end of prescribed testing, rats received two more trials (injections 14 and 15) to compare performance under usual illumination with performance under darkness with no visible light in the testing room. |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Ray, Laura B.; McMaster University; Sleep Well |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.5 mg/kg) infralimbic cortex (ILc) NMDA lesion lesion effect on expression of established behavior repeated injections of saline vehicle video recording digitized track record plot of routes of locomotion
repeated testing
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repeated trials per rat 14 or 15 trials available 1717 number of rats 120 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-08-06 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 |
| URI: | https://doi.org/10.20383/102.0442 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Ray, L. (2021). Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression. Federated Research Data Repository. https://doi.org/10.20383/102.0442
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