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Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression

Description: This study (Q22) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see,
The historical context for study Q22 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". Title of the experiment in Q22 was "Effect of an NMDA lesion of the infralimbic ctx on expression of compulsive checking". For this expression study, rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the infralimbic cortex (IL) and the effect of this lesion on the expression of compulsive checking was measured. This experiment was run in 3 batches to refine success in lesioning IL. Study Q22 was also part of a second project, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where title of the experiment was "Effect of testing under infra-red illumination on the expression of sensitization and compulsive checking". This experiment was an add-on for batch 2 rats where at the end of prescribed testing, rats received two more trials (injections 14 and 15) to compare performance under usual illumination with performance under darkness with no visible light in the testing room.
Authors: Szechtman, Henry; McMaster University; ORCID iD 0000-0003-3986-4482
Dvorkin-Gheva, Anna; McMaster University; ORCID iD 0000-0001-7295-7440
Ray, Laura B.; McMaster University; Sleep Well
Keywords: animal model
obsessive compulsive disorder
compulsive checking behavior
motor activity
behavioral sensitization
security motivation system
male rats Long-Evans
open field
large testing environment 160x160 cm
dopamine receptor agonist
chronic treatment with quinpirole (0.5 mg/kg)
infralimbic cortex (ILc) NMDA lesion
lesion effect on expression of established behavior
repeated injections of saline vehicle
video recording
digitized track record
plot of routes of locomotion
repeated testing
repeated trials per rat 14 or 15
trials available 1717
number of rats 120
Field of Research: 
Biological sciences
Neurosciences, biological and chemical aspects
Behavioural neuroscience of reward and motivation

Basic medicine and life sciences
Neurosciences, medical and physiological and health aspects
Neurosciences, medical and health and physiological aspects, not elsewhere classified

Psychology and cognitive sciences
Psychology, social and behavioural aspects

Psychology and cognitive sciences
Cognitive sciences
Cognitive behaviour
Publication Date: 2021-08-06
Publisher: Federated Research Data Repository / dépôt fédéré de données de recherche
Funder: Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424
Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544
Related Identifiers: 

This dataset is supplemented by

This dataset is supplemented by

Geographic Coverage: 
Place Name
Health Sciences Centre, McMaster University
Province /
Province / Territory
Geographic Point: 
Appears in Collections:A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection

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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0)
Szechtman, H., Dvorkin-Gheva, A., Ray, L. (2021). Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression. Federated Research Data Repository.