The Dynamic Brain Circuits and Connections in Health and Disease research cluster at the University of British Columbia consists of 30 researchers whose work in neuroscience span multiple organisms and research modalities from worms to humans. A central focus of the UBC Brain Circuits Cluster is the study of brain connections and their dynamic changes during development, learning, and how they are altered in disease. Mapping the brain’s vital wiring diagram called the “connectome” represents the structural and functional circuits between brain cells that underlies all brain function. Virtually all aspects of brain imaging from animal synapse work to human PET and MRI reflect activity within these connections. Brain Circuits-based research is a logical step towards developing circuit-based treatments for brain disease.